منابع مشابه
Mutation studies with human fibroblasts.
My attitude toward studying mutation in human fibroblasts at this time is related to that expressed by Dylan Thomas in a note to his "Collected Poems" (1): "I read somewhere of a shepherd who, when asked why he made, from within fairy rings, ritual observances to the moon to protect his flocks, replied: 'I'd be a damn fool if I didn't!' These poems, with all their crudities, doubts, and confusi...
متن کاملStudies on cell communication with enucleated human fibroblasts
Metabolic cooperation, the correction of the mutant phenotype in cells deficient in hypoxanthine phosphoribosyltransferase (HPRT-) by intimate contact with normal cells (HPRT+), represents a form of cell communication that is easily studied with radioautography. In the present study it was found that the formation of cell junctions needed for communication does not require protein synthesis nor...
متن کاملDynamic studies of human corneal fibroblasts.
Keratocytes ordinarily exist in a quiescent state. However, following injury or after surgery they become activated and fibroblastic and drive the repair of the corneal matrix, a process that is highly dynamic and occurs in three dimensions (3D). Previously, MironMendoza and associates used time-lapse microscopy to study the migration of human corneal fibroblasts out of compressed extracellular...
متن کاملMutation rate of a microsatellite sequence in normal human fibroblasts.
Dinucleotide repeats, because of their repetitive nature, are prone to frameshift mutations, most likely via a DNA-polymerase slippage mechanism. Mutation rates in microsatellite DNA sequences are high in mismatch repair-defective cells. In normal cells, only estimates of maximal rates of mutation in microsatellites have been possible previously, because of the low sensitivity of screening assa...
متن کاملInteractions of human cytomegalovirus with human fibroblasts.
Vonka, Vladimir (Baylor University College of Medicine, Houston, Tex.), and Matilda Benyesh-Melnick. Interactions of human cytomegalovirus with human fibroblasts. J. Bacteriol. 91:213-220. 1966.-Virus attachment of human cytomegalovirus to human embryo lung fibroblasts was found to be temperature-independent, from 4 to 37 C. Prolonged incubation at 4 C, however, resulted in inactivation of a hi...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1973
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.7306127